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< Study report on Probiotics (For Human) >

Section I: Bacterial Diarrhea

1. Inhibition of growth of some Enteropathogenic strains in mixed culture of Streptococcus faecalis and Clostridium butyricum

- Microbios Letters; 40, 151-180, 1989

2. Growth of other bacteria with symbiosis of Streptococcus faecalis and Clostridium butyricum in the continuous flow culture system

- Tokyo University of Pharmacy; 1986

3. Inhibitory action of Streptococcus faecalis and Clostridium butyricum against enterohemorrhagic E.coli (E.coli O-157) in the continuous flow culture

- Iyaku-no-mon; Vol. 31, No. 3, 1991

4. A case having succeeded in eliminating drug resistant Salmonella by the administration of a live bacterial preparation

- Medicine & Pharmaceutical Science; 29 (4), 1027-1030, 1993

5. Clinical result of the intestinal remedy (BIO-THREE®) containing three live bacteria species for bacterial diarrhea

- Progress in Medicine; Vol. 13, No. 3, 1993

6. Inhibition of Methicillin-Resistant Staphylococcus aureus (MRSA) in the continuous flow culture system to Streptococcus faecalis and Clostridium butyricum

- Iyaku-no-Mon; Vol. 33 (2), 71-74, 1993

7. Studies on microbiological characteristics in Enterococus preparations

- Japanese Journal of Pharmaceutical Health Care and Sciences; Vol. 19, No. 4, 1993

8. Estimation of Probiotics by infection model of infant rabbit with Enterohemorrhagic Escherichia coli O157: H7

- Journal of the Japanese Association for Infectious Disease, 1300-1305, 1998

9. Probiotics have clinical, microbiologic and immunologic efficacy in acute infectious diarrhea

- The Pediatric Infectious Disease Journal; Vol. 29, No. 2, 2010



Section II: Abnormal Bowel Movement

1. Clinical report of treating Abnormal Bowel Movement by BIO-THREE

- Iyaku-no-Mon; 29 (4), 221-224, 1989

2. Clinical records using BIO-THREE combined with other medication to treat various symptoms of Irritable Bowel Syndrome

- Diagnosis and Therapy; 80 (supple) 702-704, 1992

3. Effect of administration of BIO-THREE on abnormal bowel movement from endocrine and rheumatic diseases

- Medicine & Pharmaceutical Science; 31 (5), 1483-1487, 1994



Section III: Neonatal Infection

1. Nutrition Management on Low Birth Weight Infants with Infection

- JJPEN, Vol. 21, No. 2, 1999

2. Does Probiotics administration decrease Serum Endotoxin levels in infants?

- Journal of Paediatric Surgery; No. 34, No. 2 (Feb), 273-276, 1999

3. A review of Neonatal Infection in the NICU

- Shusanki Igaku; Vol. 30, No. 12, 2000



Section IV: Others

1. Stimulation of bacterial growth of some strains of Bifidobacterium by a crude preparation of metabolites from Bacillus mesentericus TO-A

- Biomedical Letters; 48, 73-78, 1993

2. The effects of a division-promoting factor for Bifidobacterium produced by Bacillus mesentericus on bacterial flora in the rat caecum

- Microbios; 80, 49-53, 1994

3. Characterization of Enterococcus strains contained in Probiotics products

- Biol. Pharm. Bull.; 34 (9) 1469-1473, 2011

4. Probiotics reduce infectious complications after Pancreaticoduodenectomy

- Hepato-Gastroenterology; 54, 2007

5. Clinical effectiveness of Probiotics therapy (BIO-THREE) in patients with ulcerative colitis refractory to conventional therapy

- Scandinavian Journal of Gastroenterology; 42, 1306-1311, 2007

6. Clostridium butyricum TO-A culture supernatant down-regulates TLR in human colonic epithelial cells

- Dig Dis Sci.; 52, 2963-2971, 2007

7. Effects of Probiotics on the bacterial translocation in patients with schizophrenia

- Nippon Mibyo System Gakkai Zasshi; 10 (2), 237-244, 2004



< Study report on Probiotics (For Livestock) >

1. Effects of feeding Probiotics on the localization of cells containing immunoreactive Interleukin-6 in the intestine of broiler chicks

- Japan Poultry Science; 47, 250-255, 2010

2. Effects of low dose "BIO-THREE Ace" administered to Japanese black-furred fattening cattle

- Presented at the meeting of Japan Veterinary Association in Kyushu district; November 2004

3. Effects of BIO-THREE administered for the purpose of preventing pigletfs disease and improving the fattening outcome in growing-finishing pigs

- Presented at the meeting of Japan Veterinary Association in Kyushu district; November 2006

4. Pigletfs growth test by feeding of "BIO-THREE PZ", an organic zinc-added probiotics

- SPF pig farm, Hakuba; 2006




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